Spyre Therapeutics, Inc. - Common Stock (SYRE)
43.45
-0.73 (-1.65%)
NASDAQ · Last Trade: Feb 24th, 10:18 PM EST
Detailed Quote
| Previous Close | 44.18 |
|---|---|
| Open | 44.17 |
| Bid | 40.01 |
| Ask | 46.05 |
| Day's Range | 43.05 - 44.81 |
| 52 Week Range | 10.91 - 45.76 |
| Volume | 636,487 |
| Market Cap | 4.40B |
| PE Ratio (TTM) | -35.04 |
| EPS (TTM) | -1.2 |
| Dividend & Yield | N/A (N/A) |
| 1 Month Average Volume | 718,819 |
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About Spyre Therapeutics, Inc. - Common Stock (SYRE)
Spyre Therapeutics, Inc. is a biotechnology company focused on developing innovative therapies that target specific diseases with an emphasis on precision medicine. The company is dedicated to advancing treatments through cutting-edge research and development, harnessing the potential of novel drug candidates to address unmet medical needs. By leveraging advanced technology and a deep understanding of disease mechanisms, Spyre Therapeutics aims to improve patient outcomes and quality of life across various therapeutic areas. The company's commitment to scientific excellence and collaboration drives its mission to bring transformative solutions to healthcare. Read More
News & Press Releases
WALTHAM, Mass., Feb. 24, 2026 (GLOBE NEWSWIRE) -- Spyre Therapeutics, Inc. (NASDAQ: SYRE), a clinical-stage biotechnology company pioneering long-acting antibodies and antibody combinations to redefine the standard of care for inflammatory bowel disease (“IBD”) and rheumatic diseases, today announced that management will participate in the following upcoming investor conferences:
By Spyre Therapeutics, Inc. · Via GlobeNewswire · February 24, 2026

Agios Pharmaceuticals develops therapies for rare blood disorders, anchored by its PYRUKYND franchise and early-stage clinical programs.
Via The Motley Fool · February 23, 2026

Viridian Therapeutics develops monoclonal antibody therapies targeting rare diseases, with a focus on thyroid eye disease treatments.
Via The Motley Fool · February 23, 2026

Spyre Therapeutics develops preclinical monoclonal antibody therapies targeting inflammatory bowel disease and related conditions.
Via The Motley Fool · February 23, 2026

Centessa Pharmaceuticals develops clinical-stage therapies for rare and serious diseases, leveraging a portfolio approach in biopharma.
Via The Motley Fool · February 23, 2026

Nuvalent develops targeted cancer therapies, advancing clinical candidates for patients with limited treatment options in oncology.
Via The Motley Fool · February 23, 2026
On track for 6 proof-of-concept readouts in 2026 across the SKYLINE and SKYWAY Phase 2 trials
By Spyre Therapeutics, Inc. · Via GlobeNewswire · February 19, 2026
WALTHAM, Mass., Feb. 18, 2026 (GLOBE NEWSWIRE) -- Spyre Therapeutics, Inc. (NASDAQ: SYRE), a clinical-stage biotechnology company pioneering long-acting antibodies and antibody combinations to redefine the standard of care for inflammatory bowel disease (“IBD”) and rheumatic diseases, today announced scientific presentations at the 21st Congress of the European Crohn’s and Colitis Organisation (ECCO), held February 18-21, 2026 in Stockholm, Sweden.
By Spyre Therapeutics, Inc. · Via GlobeNewswire · February 18, 2026
“6 in ’26” expected proof-of-concept (POC) readouts across SKYLINE and SKYWAY trials
By Spyre Therapeutics, Inc. · Via GlobeNewswire · January 12, 2026
Spyre Therapeutics' CEO Sells 15,000 Sharesfool.com
This biotech innovator in antibody therapies for inflammatory bowel disease reported a notable insider sale, according to a recent SEC filing.
Via The Motley Fool · January 11, 2026
Reported positive interim Phase 1 results for SPY003, a next-generation anti-IL-23 antibody, demonstrating the molecule was well-tolerated and exhibited an ~85-day half-life supporting quarterly or twice annual maintenance dosing
By Spyre Therapeutics, Inc. · Via GlobeNewswire · November 4, 2025
SPY003 was well tolerated and exhibited an ~85-day half-life, supporting potential quarterly or twice annual maintenance dosing
By Spyre Therapeutics, Inc. · Via GlobeNewswire · November 4, 2025
WALTHAM, Mass., Oct. 29, 2025 (GLOBE NEWSWIRE) -- Spyre Therapeutics, Inc. (NASDAQ: SYRE), a clinical-stage biotechnology company pioneering long-acting antibodies and antibody combinations to redefine the standard of care for inflammatory bowel disease (“IBD”) and rheumatic diseases, today announced that management will participate in the following upcoming investor conferences:
By Spyre Therapeutics, Inc. · Via GlobeNewswire · October 29, 2025
WALTHAM, Mass., Oct. 24, 2025 (GLOBE NEWSWIRE) -- Spyre Therapeutics, Inc. (NASDAQ: SYRE), a clinical-stage biotechnology company pioneering long-acting antibodies and antibody combinations to redefine the standard of care for inflammatory bowel disease (“IBD”) and rheumatic diseases, today announced scientific presentations at the ACR Convergence Congress.
By Spyre Therapeutics, Inc. · Via GlobeNewswire · October 24, 2025
WALTHAM, Mass., Oct. 15, 2025 (GLOBE NEWSWIRE) -- Spyre Therapeutics, Inc. (“Spyre” or the “Company”) (Nasdaq: SYRE), a clinical-stage biotechnology company advancing best-in-class antibody engineering, dose optimization, and rational therapeutic combinations for the treatment of Inflammatory Bowel Disease (“IBD”) and other immune-mediated diseases, today announced the closing of its previously announced underwritten public offering of 17,094,594 shares of its common stock, including the full exercise of the underwriters’ option to purchase up to 2,229,729 additional shares, at a public offering price per share of $18.50. The gross proceeds to Spyre from the offering were approximately $316.2 million before deducting underwriting discounts and commissions and other offering expenses payable by Spyre.
By Spyre Therapeutics, Inc. · Via GlobeNewswire · October 15, 2025
Via Benzinga · October 14, 2025
WALTHAM, Mass., Oct. 13, 2025 (GLOBE NEWSWIRE) -- Spyre Therapeutics, Inc. (“Spyre” or the “Company”) (Nasdaq: SYRE), a clinical-stage biotechnology company advancing best-in-class antibody engineering, dose optimization, and rational therapeutic combinations for the treatment of Inflammatory Bowel Disease (“IBD”) and other immune-mediated diseases, today announced the pricing of its previously announced underwritten public offering of 14,864,865 shares of its common stock at a price to the public of $18.50 per share. The gross proceeds to the Company from this offering are expected to be approximately $275.0 million, before deducting underwriting discounts and commissions and other offering expenses. In addition, the Company has granted the underwriters of the offering an option for a period of 30 days to purchase up to an additional 2,229,729 shares of the Company's common stock at the public offering price, less the underwriting discount.
By Spyre Therapeutics, Inc. · Via GlobeNewswire · October 13, 2025
WALTHAM, Mass., Oct. 13, 2025 (GLOBE NEWSWIRE) -- Spyre Therapeutics, Inc. (“Spyre” or the “Company”) (Nasdaq: SYRE), a clinical-stage biotechnology company advancing best-in-class antibody engineering, dose optimization, and rational therapeutic combinations for the treatment of Inflammatory Bowel Disease (“IBD”) and other immune-mediated diseases, today announced that it has commenced an underwritten public offering of shares of its common stock or, in lieu of issuing common stock to certain investors, pre-funded warrants to purchase shares of its common stock. In addition, the Company is expected to grant the underwriters of the offering an option for a period of 30 days to purchase additional shares of common stock at the public offering price, less the underwriting discount. All of the shares of common stock and pre-funded warrants in the offering will be sold by Spyre.
By Spyre Therapeutics, Inc. · Via GlobeNewswire · October 13, 2025
Via Benzinga · October 10, 2025
WALTHAM, Mass., Oct. 05, 2025 (GLOBE NEWSWIRE) -- Spyre Therapeutics, Inc. (NASDAQ: SYRE), a clinical-stage biotechnology company advancing best-in-class antibody engineering, dose optimization, and rational therapeutic combinations for the treatment of Inflammatory Bowel Disease (“IBD”) and other immune-mediated diseases, today announced scientific presentations at the UEGW Congress.
By Spyre Therapeutics, Inc. · Via GlobeNewswire · October 5, 2025
Top Wall Street analysts changed their outlook on these top names. For a complete view of all analyst rating changes, including upgrades, downgrades and initiations, please see our analyst ratings page.
Via Benzinga · September 26, 2025
SPY072 is a potential first- and best-in-class anti-TL1A antibody for rheumatic diseases targeting quarterly or twice-yearly subcutaneous dosing
By Spyre Therapeutics, Inc. · Via GlobeNewswire · September 15, 2025
Via Benzinga · April 8, 2025

NEW YORK, Dec. 03, 2024 (GLOBE NEWSWIRE) -- Bragar Eagel & Squire, P.C., a nationally recognized stockholder rights law firm, is investigating potential claims against Spyre Therapeutics, Inc. (“Spyre” or the “Company”) (NASDAQ:SYRE) on behalf of Spyre stockholders. Our investigation concerns whether Spyre has violated the federal securities laws and/or engaged in other unlawful business practices.
By Bragar Eagel & Squire · Via GlobeNewswire · December 3, 2024
